全凭静脉或吸入麻醉对食管癌手术患者的影响：回顾性不雅察参谋
作家：米勒之声
全凭静脉或吸入麻醉对食管癌手术患者的影响：回顾性不雅察参谋
贵州医科大学 麻醉与腹黑电生理课题组
翻译 : 文春雷 裁剪 : 严旭 审校 : 曹莹
布景：不同的麻醉药对免疫系统可能有相背的影响，从而影响肿瘤患者的预后。细胞介导的免疫是顽抗肿瘤细胞侵袭的主要防御本事，因此增强免疫系统的抗肿瘤反馈不错动作一种肿瘤缓助协调。七氟醚具有促炎症作用，而异丙酚具有抗炎症和抗氧化作用。因此，咱们比拟了全凭静脉麻醉和吸入麻醉下食管癌患者的总糊口期（OS）和无病糊口期（DFS）。
重要：本参谋荟萃了2014年1月1日至2016年12月31日剿袭食管切除术患者的电子病历。证实术中麻醉式样的不同，将患者分为全凭静脉麻醉（TIVA）组和吸入麻醉（INHA）组。接纳融会的逆概率责罚加权（SIPTW）来最小化偏差。建筑Kaplan-Meier糊口弧线，评价不同麻醉重要与食管癌手术患者总糊口期与无病糊口期的谈论性。
服从：共荟萃420例食管癌患者病历，其中363例得当参谋条目的患者（TIVA，n=147，INHA，n=216）。SIPTW责罚后，两组患者的总糊口期和无病糊口期均无权臣相反。关联词，缓助协调对改善OS有统计学敬爱，且肿瘤分化进度与OS和DFS谈论。
论断：总而言之，食管癌手术患者全凭静脉麻醉和吸入麻醉的总糊口期和无病糊口期均无权臣相反。
原始文件开首：
Yue Ma, Jie Ren, Zhuo Chen,et al.Outcomes of intravenous and inhalation anesthesia on patients undergoing esophageal cancer surgery: a retrospective observational study.[J].BMC Anesthesiology （2023）23:66.
英文原文
Outcomes of intravenous and inhalation
anesthesia on patients undergoing esophageal cancer surgery: a retrospective observational
study
Background: Diferent anesthetics may have opposite efects on the immune system, thus afecting the prognosis of tumor patients. Cell-mediated immunity forms the primary defense against the invasion of tumor cells, so manipulation of the immune system to produce an enhanced anti-tumor response could be utilized as an adjuvant oncological therapy. Sevofurane has proinfammatory efects, while propofol, has anti-infammatory and antioxidant efects. Therefore, we compared the overall survival (OS) and disease-free survival (DFS) of patients with esophageal cancer under total intravenous anesthesia and inhalation anesthesia.
Methods:This study collected the electronic medical records of patients undergoing esophagectomy from January 1, 2014 to December 31, 2016. According to the intraoperative anesthetics, the patients were divided into total intravenous anesthesia (TIVA) group or inhalational anesthesia (INHA) group. Stabilized inverse probability of treatment weighting (SIPTW) was used to minimize diferences. Kaplan–Meier survival curve was established to evaluate the correlation between diferent anesthesia methods in overall survival and disease-free survival of patients undergoing esophageal cancer surgery.
Results:A total of 420 patients with elective esophageal cancer were collected, including 363 patients eligible for study (TIVA, n=147, INHA, n=216). After SIPTW there were no signifcant diferences between two groups in overall survival and disease-free survival. However, the adjuvant therapy was statistically signifcant in improving OS, and the degree of diferentiation was correlated with OS and DFS.
Conclusions:In conclusion, there were no signifcant diference in overall survival and disease-free survival between total intravenous anesthesia and inhalational anesthesia in patients undergoing esophageal cancer surgery.
CORPORATE CULTURE
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裁剪：Michel.米萱
校对：MiLu.米鹭
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糊口期and食管癌cancer患者发布于：北京市声明：该文不雅点仅代表作家本东说念主，搜狐号系信息发布平台，搜狐仅提供信息存储空间作事。